Gabapentin (GBP)

1) The main possible mechanism: voltage-gated sodium channel blocker (N-type and P/Q-type).

2) Therapeutic indications: Adjunctive therapy in the treatment of focal onset seizures (generally required to be at least 3 years old).

3) Warning: It is often ineffective or even aggravated in epilepsy with generalized seizures. In addition, it is relatively rarely used in children and is mainly used for non-epileptic diseases such as postherpetic neuralgia.

4) Dosage for children: Click to view the dosage for children of different ages and weights.

5) Major adverse reactions in children: Some may experience an increase in appetite and weight, as well as mental and behavioral abnormalities, and some may also experience drowsiness, dizziness, fatigue, double vision, abnormal sensation, and forgetfulness.

6) Interaction with other anti-epileptic drugs: Can significantly reduce the clearance rate of felbamate.

7) Interaction with non-anti-epileptic drugs: Cimetidine can reduce its renal clearance rate (gabapentin is not metabolized in the body and is completely excreted in the urine unchanged), and acid-suppressing drugs can reduce the absorption rate of gabapentin by 20%.

Gabapentin Instructions:

FDA, EMC.