Oxcarbazepine (OXC)

1) The main possible mechanism: voltage-gated sodium channel blocker.

2) Therapeutic indications: mainly suitable for focal epilepsy.

3) Warning: avoid use in children with atrioventricular block; It should be used with caution in the type of seizure that is manifested as absence, atonic or myoclonic, and it may be aggravated after use. 

4) Dosage for children: Click to view the dosage for children of different ages and weights.

5) Major adverse reactions in children: Allergic rash (but the incidence is lower than that of carbamazepine. If a patient is allergic to carbamazepine, there is a 25% chance that it will also cause an allergy to this drug. Try not to choose it). In addition, long-term use may cause hyponatremia (this situation is more common than carbamazepine, but most of it is benign, generally reducing fluid intake or reducing the dose of medication can be restored). Some patients will have some non-specific side effects related to the dose, such as headache, dizziness, diplopia, nausea, fatigue, drowsiness, ataxia and so on.

6) Interaction with other anti-epileptic drugs: Oxcarbazepine can reduce the blood concentration of perampanel by about 1.9 times.

7) Interaction with non-anti-epileptic drugs: Relatively few.

Oxcarbazepine Instructions:

FDA, EMC.