English 
简体中文 Topiramate (TPM)
1) The main possible mechanism: A combination of multiple mechanisms of action, mainly including voltage-gated sodium channel blocker.
2) Therapeutic indications: a broad-spectrum anti-epileptic drug (better for focal seizures).
3) Warning: Patients with metabolic acidosis, kidney stones, and elevated intraocular pressure (such as glaucoma) should be avoided as much as possible. In contrast to sodium valproate, the drug is not suitable for very thin patients because it may reduce weight.
4) Dosage for children: Click to view the dosage for children of different ages and weights.
5) Major adverse reactions in children: acute angle closure glaucoma (but rare), if taken for a long time, some patients will also have kidney stones and weight loss (it is also an advantage, which some obese people will like), metabolic acidosis, etc. If the dose is too large or increased too quickly, paresthesias, anorexia, as well as attention, memory and language disorders are prone to occur. In addition, it tend to cause decreased sweating (more obvious in infants).
6) Interaction with other anti-epileptic drugs: It also has an inhibitory effect on liver enzymes and can increase the concentration of phenytoin sodium (but the concentration of topiramate itself will be lowered by phenytoin sodium), and carbamazepine can reduce the blood concentration of topiramate. In addition, try to avoid being combined with other antiepileptic drugs that also inhibit carbonic anhydrase enzyme, such as zonisamide.
7) Interaction with non-anti-epileptic drugs: Relatively few. Avoid combining with some drugs that are also easy to form kidney stones.