Pregabalin (PGB)

1) The main possible mechanism: voltage-gated sodium channel blocker (similar to gabapentin, but has higher affinity for the α2δ subunit of calcium channels).

2) Therapeutic indications: Adjunctive therapy in the treatment of focal onset seizures.

3) Warning: It is generally not used for epilepsy with generalized seizures and it may aggravate myoclonic seizures.

4) Dosage for children: Click to view the dosage for children of different ages and weights.

5) Major adverse reactions in children: Increased weight and appetite are common, and some may also experience dizziness, somnolence, dry mouth, edema, blurred vision, and difficulty with concentration/attention.

6) Interaction with other anti-epileptic drugs: There are no significant interactions with other anti-epileptic drugs (predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans, and does not bind to plasma proteins).

7) Interaction with non-anti-epileptic drugs: increase the pharmacological effects of lorazepam and ethanol.

Pregabalin Instructions:

FDA.