Tiagabine (TGB)

1) The main possible mechanism: Increase GABA levels in the brain.

2) Therapeutic indications: Adjuvant treatment of focal seizures in children aged 12 years and older.

3) Warning: It is contraindicated in idiopathic generalized epilepsy associated with absence seizures, as it may induce status absence seizures.

4) Dosage for children: Click to view the dosage for children of different ages and weights.

5) Major adverse reactions in children: Dizziness and fatigue are common. In addition, tremors, cognitive impairment, attention disorders, depression, difficulty in word formation, etc. may occur in some cases.

6) Interaction with other anti-epileptic drugs: Liver enzyme-inducing anti-epileptic drugs, such as phenytoin, phenobarbital, carbamazepine, etc. can significantly reduce the blood concentration of tiagabine (the concentration can be reduced to 1/3 to 2/3 of the original level). Valproate sodium can displace tigabine from the protein binding site (in vitro tests, clinical significance is unclear).

7) Interaction with non-anti-epileptic drugs: still not clear.

Tiagabine Instructions:

FDA, EMC.