Stiripentol (STP)

1) The main possible mechanism: Increase the content of GABA in the brain, in addition to indirectly increase the plasma concentration of other antiepileptic drugs (such as sodium valproate, clobazam, etc.).

2) Therapeutic indications: It is mainly used in combination with sodium valproate and clobazam to treat Dravet Syndrome.

3) Warning: Other types of epilepsy are generally not used.

4) Dosage for children: Click to view the dosage for children of different ages and weights.

5) Major adverse reactions in children: Anorexia, weight loss, insomnia, lethargy, ataxia, hypotonia, vomiting.

6) Interaction with other anti-epileptic drugs: Can increase the concentration of phenobarbital, phenytoin sodium, carbamazepine, sodium valproate, clobazam and other benzodiazepines.

7) Interaction with non-anti-epileptic drugs: It can increase the concentration of theophylline, antihistamine and other drugs.

Stiripentol Instructions:

FDA, EMC.